abstract：:Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...

journal_title：Lupus

authors： Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene, which was identified as a candidate gene for SLE susceptibility in lupus mouse model. We determined these gene expressions in leukocytes from 20 SLE patients and 10 healthy controls and in renal biopsies from 29 SLE patients and 15 kidney donor...

journal_title：Lupus

authors： Kimkong I,Avihingsanon Y,Hirankarn N

更新日期：2009-10-01 00:00:00

abstract：:The objective of this study is to determine if digital vasculitis (DV), a clinical manifestation with a high systemic lupus erythematosus disease activity index (SLEDAI) score, is associated with lupus severity. DV and other clinical manifestations defined according to the SLEDAI were evaluated in 168 consecutive pati...

journal_title：Lupus

authors： Gomes C,Carvalho JF,Borba EF,Borges CT,Vendramini MB,Bueno C,Costa LP,Bonfá E

更新日期：2009-10-01 00:00:00

abstract：:The registry is a prospective, European, multicentric, longitudinal study, which follows a cohort of children born to mothers with antiphospholipid syndrome (APS). It was started in 2003. In this report, we update the results obtained from the study of 110 mothers and 112 children (two twin births). Eighty per cent of...

journal_title：Lupus

authors： Boffa MC,Lachassinne E,Boinot C,De Carolis S,Rovere-Querini P,Avcin T,Biasini-Rebaioli C,Le Toumelin P,Aurousseau MH,Tincani A

更新日期：2009-09-01 00:00:00

abstract：:The complexity of the therapeutic approach in systemic lupus erythematosus (SLE) is increased by the large number of patients who do not respond to the first-line therapies and by relapses after initial clinical remission. In these patients, second-line drugs are often prescribed according to individual clinical decis...

journal_title：Lupus

authors： Ramos-Casals M,Soto MJ,Cuadrado MJ,Khamashta MA

更新日期：2009-08-01 00:00:00

abstract：:This report considers the rare situation in which primary antiphospholipid syndrome (PAPS) is linked with thrombotic thrombocytopenic purpura (TTP). It describes the case of a young lady with PAPS, characterized by recurring cerebro-vascular abnormalities and marked livedo reticularis, combined with circulating antica...

journal_title：Lupus

authors： de Carvalho JF,Freitas CA,Lima IV,Leite CC,Lage LV

更新日期：2009-08-01 00:00:00

abstract：:To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...

journal_title：Lupus

authors： Cavazzana I,Sala R,Bazzani C,Ceribelli A,Zane C,Cattaneo R,Tincani A,Calzavara-Pinton PG,Franceschini F

更新日期：2009-07-01 00:00:00

abstract：:Pericardial effusions causing pericardial tamponade are rare in patients with systemic lupus erythematosus (SLE). The goal of this study is to describe in detail the clinical and laboratory characteristics of a group of patients with pericardial effusions and pericardial tamponade secondary to SLE. We retrospectively ...

journal_title：Lupus

authors： Rosenbaum E,Krebs E,Cohen M,Tiliakos A,Derk CT

更新日期：2009-06-01 00:00:00

abstract：:The purpose of study was to determine the nature, outcomes and associated risk factors of invasive fungal infection (IFI) in patients with systemic lupus erythematosus (SLE), and compare the incidence of IFI in patients with rheumatoid arthritis (RA). A total of 1155 patients with SLE and 2004 patients with RA were re...

journal_title：Lupus

authors： Kim HJ,Park YJ,Kim WU,Park SH,Cho CS

更新日期：2009-06-01 00:00:00

abstract：:Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...

journal_title：Lupus

authors： Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

更新日期：2009-05-01 00:00:00

abstract：:Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...

journal_title：Lupus

authors： Lin YQ,Lakshminarayanan S,Yamase H,Palmisano J,Parke A

更新日期：2009-05-01 00:00:00

abstract：:Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...

journal_title：Lupus

authors： Anam K,Amare M,Naik S,Szabo KA,Davis TA

更新日期：2009-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). We sought to evaluate its efficacy in reducing the number of disease flares in adults with SLE. For this retrospective study, all patients seen at our institution over a six year period, 1999-2005, wit...

journal_title：Lupus

authors： Nannini C,Crowson CS,Matteson EL,Moder KG

更新日期：2009-04-01 00:00:00

abstract：:Eosinophilic gastroenteritis (EGE) is an uncommon disease and has rarely been reported in association with connective tissue diseases as systemic lupus erythematosus. We report a 36-year-old woman who developed recurrent episodes of abdominal pain, nausea, vomiting and melena. Complete blood counts showed elevated eos...

journal_title：Lupus

authors： Jaimes-Hernandez J,Aranda-Peirera P,Melendez-Mercado CI

更新日期：2009-04-01 00:00:00

abstract：:The objective of this study is to investigate the presence of anti-nucleosome (anti-NCS) and anti-chromatin (anti-CRT) antibodies in patients with cutaneous lupus erythematosus (CLE) compared with active and inactive systemic lupus erythematosus (SLE). A total of 154 subjects were evaluated: 54 patients presenting CLE...

journal_title：Lupus

authors： Souza A,da Silva LM,Oliveira FR,Roselino AM,Louzada-Junior P

更新日期：2009-03-01 00:00:00

abstract：:We performed a retrospective study of all systemic lupus erythematosus (SLE) pregnancies during a two-year period (2006-2007) to describe the clinical features, maternal and foetal outcomes in our centre. There were 17 pregnancies in 16 women with SLE. Our patients have a mean age of 28.31 years (SD 5.24) and a mean d...

journal_title：Lupus

authors： Teh CL,Wong JS,Ngeh NK,Loh WL

更新日期：2009-03-01 00:00:00

abstract：:The use of TNF alpha (TNFalpha) inhibitors has made a strong impact on the management of rheumatoid and psoriatic arthritis, ankylosing spondylitis and Crohn disease. Side effects of these agents include the development of autoantibodies and a lupus-like syndrome (drug-related lupus, DRL). Here, a case of a patient wh...

journal_title：Lupus

authors： Kocharla L,Mongey AB

更新日期：2009-02-01 00:00:00

abstract：:The p53 tumour suppressor is the central regulator of apoptosis. Previously, the functional TP53 Arg72Pro polymorphism was found to be associated with systemic lupus erythematosus (SLE) in Koreans but not Spaniards. MDM2 is the major negative regulator of p53. An intronic polymorphism in MDM2, the SNP309, attenuates p...

journal_title：Lupus

authors： Onel KB,Huo D,Hastings D,Fryer-Biggs J,Crow MK,Onel K

更新日期：2009-01-01 00:00:00

abstract：:To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...

journal_title：Lupus

authors： Duran-Barragan S,Ruvalcaba-Naranjo H,Rodriguez-Gutierrez L,Solano-Moreno H,Hernandez-Rios G,Sanchez-Ortiz A,Ramos-Remus C

更新日期：2008-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...

journal_title：Lupus

authors： Cortes S,Chambers S,Jerónimo A,Isenberg D

更新日期：2008-11-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a rare, deadly demyelinating disease of the central nervous system, which is caused by a reactivation of the DNA polyomavirus JC and occurs in immunosuppressed individuals. So far, only 25 cases have been described in patients with SLE and none survived without antiv...

journal_title：Lupus

authors： Nived O,Bengtsson AA,Jönsen A,Sturfelt G

更新日期：2008-11-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial....

journal_title：Lupus

authors： Cockrell E,Espinola RG,McCrae KR

更新日期：2008-10-01 00:00:00

abstract：:To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

journal_title：Lupus

authors： Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

更新日期：2008-09-01 00:00:00

abstract：:We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....

journal_title：Lupus

authors： Cavazzana I,Ceribelli A,Quinzanini M,Scarsi M,Airò P,Cattaneo R,Franceschini F

更新日期：2008-08-01 00:00:00

abstract：:This study was conducted to determine kidney transplantation (KTx) outcomes for Greek patients with renal failure caused by lupus nephritis (LN) compared with matched controls, kidney recipients with other causes of end-stage renal disease (ESRD). Twenty-six patients with systemic lupus erythematosus (SLE) subjected t...

journal_title：Lupus

authors： Lionaki S,Kapitsinou PP,Iniotaki A,Kostakis A,Moutsopoulos HM,Boletis JN

更新日期：2008-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...

journal_title：Lupus

authors： Abdel-Aty H,Siegle N,Natusch A,Gromnica-Ihle E,Wassmuth R,Dietz R,Schulz-Menger J

更新日期：2008-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...

journal_title：Lupus

authors： Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

更新日期：2008-05-01 00:00:00

abstract：:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...

journal_title：Lupus

authors： La Cava A

更新日期：2008-05-01 00:00:00

abstract：:The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar flu...

journal_title：Lupus

authors： Rojas-Serrano J,Pedroza J,Regalado J,Robledo J,Reyes E,Sifuentes-Osornio J,Flores-Suárez LF

更新日期：2008-04-01 00:00:00

abstract：:Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...

journal_title：Lupus

authors： Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AH

更新日期：2008-03-01 00:00:00

abstract：:The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...

journal_title：Lupus

authors： Wallace DJ

更新日期：2008-02-01 00:00:00

abstract：:The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...

journal_title：Lupus

authors： Piotrowski P,Lianeri M,Mostowska M,Wudarski M,Chwalinska-Sadowska H,Jagodzinski PP

更新日期：2008-02-01 00:00:00

abstract：:Recent studies have revealed new populations of T/B cells, including central/effector memory, follicular T cells and CXCR3+ or CXCR4+ B cells. In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythem...

journal_title：Lupus

authors： Watanabe T,Suzuki J,Mitsuo A,Nakano S,Tamayama Y,Katagiri A,Amano H,Morimoto S,Tokano Y,Takasaki Y

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...

journal_title：Lupus

authors： de Souza AW,Silva NP,de Carvalho JF,D'Almeida V,Noguti MA,Sato EI

更新日期：2007-01-01 00:00:00

abstract：:To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...

journal_title：Lupus

authors： Appenzeller S,Li LM,Costallat LT,Cendes F

更新日期：2007-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...

journal_title：Lupus

authors： James JA,Kim-Howard XR,Bruner BF,Jonsson MK,McClain MT,Arbuckle MR,Walker C,Dennis GJ,Merrill JT,Harley JB

更新日期：2007-01-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:The management of lupus nephritis is typified by popular misconceptions: that there is a 'standard of care', that treatment has well-defined aims and that the optimum length of treatment is established. In reality, however, uncertainties still exist and the evidence base remains weak. Until recently, initial therapy f...

journal_title：Lupus

authors： Jayne D

更新日期：2007-01-01 00:00:00

abstract：:Renal involvement in systemic lupus erythematosus is a common complication that significantly worsens morbidity and mortality. Although treatment with corticosteroids and cytotoxic drugs may be useful in many cases, morbidity associated with these drugs and the relapsing nature of the disease make it necessary to deve...

journal_title：Lupus

authors： Alperovich G,Rama I,Lloberas N,Franquesa M,Poveda R,Gomà M,Herrero-Fresneda I,Cruzado JM,Bolaños N,Carrera M,Grinyó JM,Torras J

更新日期：2007-01-01 00:00:00

abstract：:The presence of antibodies against the complex of prothrombin and phosphatidylserine (aPS/PT) more significantly correlates with manifestations of antiphospholipid syndrome (APS) and with the presence of lupus anticoagulants (LA) than antibodies against prothrombin bound to oxygenated polystyrene (aPT-A). To investiga...

journal_title：Lupus

authors： Horita T,Ichikawa K,Kataoka H,Yasuda S,Atsumi T,Koike T

更新日期：2007-01-01 00:00:00